Molecular characterization of DDX26, a human DEAD-box RNA helicase, located on chromosome 7p12

DEAD-box proteins comprise a family of ATP-dependent RNA helicases involved in several aspects of RNA metabolism. Here we report the characterization of the human DEAD-box RNA helicase DDX26. The gene is composed of 14 exons distributed over an extension of 8,123 bp of genomic sequence and encodes a transcript of 1.8 kb that is expressed in all tissues evaluated. The predicted amino acid sequence shows a high similarity to a yeast DEAD-box RNA helicase (Dbp9b) involved in ribosome biogenesis. The new helicase maps to 7p12, a region of frequent chromosome amplifications in glioblastomas involving the epidermal growth factor receptor (EGFR) gene. Nevertheless, co-amplification of DDX26 with EGFR was not detected in nine tumors analyzed.

Bibliographic Details

Main Authors:	Camargo,A.A., Nunes,D.N., Samaia,H.B., Liu,L., Collins,V.P., Simpson,A.J.G., Dias-Neto,E.
Format:	Digital revista
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2001
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000002
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