Eosinophil-active chemokines: assessment of in vivo activity
The selective recruitment of eosinophils in tissue is a striking feature of allergic diseases. Recently, a family of chemoattractant molecules, namely chemokines, has been described which potently activates eosinophil function in vitro. We have developed a murine model of eosinophil recruitment to compare the relative potency and efficacy of chemokines in vivo. Of the chemokines tested, only eotaxin and MIP-1<FONT FACE="Symbol">a</font> induced significant accumulation of eosinophils in vivo, but eotaxin was more effective than MIP-1<FONT FACE="Symbol">a</font>. Chemokines, especially eotaxin acting via the CCR-3 receptor, may have a fundamental role in determining selective eosinophil recruitment in vivo
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| Format: | Digital revista |
| Language: | English |
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Associação Brasileira de Divulgação Científica
1998
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100003 |
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