Cytogenetic study of 50 Brazilian patients with primary myelodysplastic syndrome

In this work we analyzed cytogenetically 50 patients with primary myelodysplastic syndrome from several hospitals of Rio de Janeiro, Brazil. The frequency of cytogenetic abnormalities was 32%. Patients with refractory anemia, or refractory anemia with ringed sideroblasts, presented normal karyotypes or single abnormalities such as del(5q) or -Y, while patients with refractory anemia with an excess of blasts, refractory anemia with an excess of blasts in transformation or chronic myelomonocytic leukemia showed complex karyotypes and single abnormalities involving chromosomes 7 or 8, which are related to a bad prognosis and an elevated risk of evolution to acute myeloid leukemia.

Saved in:
Bibliographic Details
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Genética 1997
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84551997000100016
Tags: Add Tag
No Tags, Be the first to tag this record!