Short-term Prophylaxis for Delivery in Pregnant Women with Hereditary Angioedema with Normal C1-Inhibitor

Abstract Objective To verify the efficacy of short-term prophylaxis for vaginal or cesarean section childbirth with plasma-derived C1-inhibitor concentrate in pregnant women. They should have hereditary angioedema (HAE) and normal plasma C1-inhibitor. Methods Case report of pregnant women diagnosed with HAE with normal C1- inhibitor who had been treated with intravenous C1-inhibitor concentrate for prophylaxis of angioedema attacks when hospitalized for delivery. The exon 9 of the Factor 12 (F12) genotyping gene was performed by automatic sequencing in all patients. Results Three cases of pregnant women with HAE with normal serum level of C1- inhibitor are reported. The genetic test detected the presence of a pathogenic mutation in the F12 gene. Deliveries occurred uneventfully and patients had no HAE symptoms in the following 72 hours. Conclusion C1-inhibitor concentrate could be useful to prevent angioedema attacks during and after delivery.

Bibliographic Details

Main Authors:	Moraes,Caroline Guth de Freitas Batista de, Mikami,Liya Regina, Ferrari,Lilian Pereira, Pesquero,João Bosco, Chong-Neto,Herberto José, Rosario Filho,Nelson Augusto
Format:	Digital revista
Language:	English
Published:	Federação Brasileira das Sociedades de Ginecologia e Obstetrícia 2020
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-72032020001200845
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