Identification of the sentinel lymph node using hemosiderin in locally advanced breast cancer

ABSTRACT Objective: to verify the agreement rate in the identification of sentinel lymph node using an autologous marker rich in hemosiderin and 99 Technetium (Tc99) in patients with locally advanced breast cancer. Methods: clinical trial phase 1, prospective, non-randomized, of 18 patients with breast cancer and clinically negative axilla stages T2=4cm, T3 and T4. Patients were submitted to sub-areolar injection of hemosiderin 48 hours prior to sentinel biopsy surgery, and the identification rate was compared at intraoperative period to the gold standard marker Tc99. Agreement between methods was determined by Kappa index. Results: identification rate of sentinel lymph node was 88.9%, with a medium of two sentinel lymph nodes per patients. The study identified sentinel lymph nodes stained by hemosiderin in 83.3% patients (n=15), and, compared to Tc99 identification, the agreement rate was 94.4%. Conclusion: autologous marker rich in hemosiderin was effective to identify sentinel lymph nodes in locally advanced breast cancer patients.

Bibliographic Details

Main Authors:	DE AGUIAR,PAULO HENRIQUE WALTER, AQUINO,RANNIERE GURGEL FURTADO DE, ALVES,MAYARA MAIA, CORREIA,JULIO MARCUS SOUSA, OLIVEIRA,AYANE LAYNE DE SOUSA, VIANA JÚNIOR,ANTÔNIO BRAZIL, PINHEIRO,LUIZ GONZAGA PORTO
Format:	Digital revista
Language:	English
Published:	Colégio Brasileiro de Cirurgiões 2017
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-69912017000600612
Tags:	Add Tag No Tags, Be the first to tag this record!