Potentiometric determination of Minoxidil in topical use pharmaceutical samples

A potentiometric titration method for the determination of minoxidil based on its redox reaction with K2Cr2O7 is described. The best results were observed using 1.00 x 10-3 mol L-1 K2Cr2O7 and 1.00 x 10-2 mol L-1 minoxidil solutions, and the minoxidil as titrant in 2.00 mol L-1 H2SO4 medium. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.4 to 98.7 % were observed depending on the sample. Comparison with the chromatographic procedure reveled agreement within 90% confidence level.

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Bibliographic Details
Main Authors: Sousa,Rogério Adelino de, Cavalheiro,Éder Tadeu Gomes
Format: Digital revista
Language:English
Published: Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP 2009
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702009000200003
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