DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith
A chemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith, a member of Annonaceae family, was carried out. The ethanolic extract from the roots of this plant led, by chromatography tecniches, to isolation of the new azaphenanthrene alkaloids dolichocarpine (1) and 9-methoxyeupolauramine (2), besides the known alkaloids eupolauramine (3), 3-methoxyeupolauridine (4), eupolauramine (5) and 4-methylsampangine (6). The structures of isolated compounds were established by 1D and 2D NMR, HRESIMS, tandem MSn and IR data. The cytotoxicity of compounds 1 - 5 was evaluated against HCT-116 (human colorectal carcinoma) and L929 (murine fibroblast) cell lines.
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Sociedade Brasileira de Química
2020
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oai:scielo:S0100-404220200006006922020-07-20DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & SandwithSales,Kaio A.Pinheiro,Anderson A. V.Araújo,Diego I. A. F.Andrade,Rodrigo S. deAgra,Maria de FátimaSobral,Marianna V.Magalhães,Hemerson I. F.Sousa,Valgrícia M. deBraz-Filho,RaimundoSilva,Marcelo S. daTavares,Josean F. Annonaceae Anaxagorea alkaloid cytotoxicity A chemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith, a member of Annonaceae family, was carried out. The ethanolic extract from the roots of this plant led, by chromatography tecniches, to isolation of the new azaphenanthrene alkaloids dolichocarpine (1) and 9-methoxyeupolauramine (2), besides the known alkaloids eupolauramine (3), 3-methoxyeupolauridine (4), eupolauramine (5) and 4-methylsampangine (6). The structures of isolated compounds were established by 1D and 2D NMR, HRESIMS, tandem MSn and IR data. The cytotoxicity of compounds 1 - 5 was evaluated against HCT-116 (human colorectal carcinoma) and L929 (murine fibroblast) cell lines.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.43 n.6 20202020-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000600692pt10.21577/0100-4042.20170529 |
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Sales,Kaio A. Pinheiro,Anderson A. V. Araújo,Diego I. A. F. Andrade,Rodrigo S. de Agra,Maria de Fátima Sobral,Marianna V. Magalhães,Hemerson I. F. Sousa,Valgrícia M. de Braz-Filho,Raimundo Silva,Marcelo S. da Tavares,Josean F. |
| spellingShingle |
Sales,Kaio A. Pinheiro,Anderson A. V. Araújo,Diego I. A. F. Andrade,Rodrigo S. de Agra,Maria de Fátima Sobral,Marianna V. Magalhães,Hemerson I. F. Sousa,Valgrícia M. de Braz-Filho,Raimundo Silva,Marcelo S. da Tavares,Josean F. DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith |
| author_facet |
Sales,Kaio A. Pinheiro,Anderson A. V. Araújo,Diego I. A. F. Andrade,Rodrigo S. de Agra,Maria de Fátima Sobral,Marianna V. Magalhães,Hemerson I. F. Sousa,Valgrícia M. de Braz-Filho,Raimundo Silva,Marcelo S. da Tavares,Josean F. |
| author_sort |
Sales,Kaio A. |
| title |
DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith |
| title_short |
DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith |
| title_full |
DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith |
| title_fullStr |
DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith |
| title_full_unstemmed |
DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith |
| title_sort |
dois novos alcaloides azafenantreno de anaxagorea dolichocarpa sprague & sandwith |
| description |
A chemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith, a member of Annonaceae family, was carried out. The ethanolic extract from the roots of this plant led, by chromatography tecniches, to isolation of the new azaphenanthrene alkaloids dolichocarpine (1) and 9-methoxyeupolauramine (2), besides the known alkaloids eupolauramine (3), 3-methoxyeupolauridine (4), eupolauramine (5) and 4-methylsampangine (6). The structures of isolated compounds were established by 1D and 2D NMR, HRESIMS, tandem MSn and IR data. The cytotoxicity of compounds 1 - 5 was evaluated against HCT-116 (human colorectal carcinoma) and L929 (murine fibroblast) cell lines. |
| publisher |
Sociedade Brasileira de Química |
| publishDate |
2020 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000600692 |
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