DOIS NOVOS ALCALOIDES AZAFENANTRENO DE Anaxagorea dolichocarpa Sprague & Sandwith

A chemical investigation of Anaxagorea dolichocarpa Sprague & Sandwith, a member of Annonaceae family, was carried out. The ethanolic extract from the roots of this plant led, by chromatography tecniches, to isolation of the new azaphenanthrene alkaloids dolichocarpine (1) and 9-methoxyeupolauramine (2), besides the known alkaloids eupolauramine (3), 3-methoxyeupolauridine (4), eupolauramine (5) and 4-methylsampangine (6). The structures of isolated compounds were established by 1D and 2D NMR, HRESIMS, tandem MSn and IR data. The cytotoxicity of compounds 1 - 5 was evaluated against HCT-116 (human colorectal carcinoma) and L929 (murine fibroblast) cell lines.

Bibliographic Details

Main Authors:	Sales,Kaio A., Pinheiro,Anderson A. V., Araújo,Diego I. A. F., Andrade,Rodrigo S. de, Agra,Maria de Fátima, Sobral,Marianna V., Magalhães,Hemerson I. F., Sousa,Valgrícia M. de, Braz-Filho,Raimundo, Silva,Marcelo S. da, Tavares,Josean F.
Format:	Digital revista
Language:	Portuguese
Published:	Sociedade Brasileira de Química 2020
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422020000600692
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