ESTRATÉGIAS DE SÍNTESE NA DESCOBERTA DE FÁRMACOS: O EMPREGO DA SÍNTESE ORIENTADA PELA DIVERSIDADE ESTRUTURAL
Drug discovery often involves screening synthetic small molecules for their ability to bind to a macromolecular target. Target-Oriented Synthesis of a specific compound or a focused library can be planned combining retrosynthetic analysis and rational drug design. Biologically active molecules also can be identified through the unfocused screening of compound libraries. Diversity-Oriented Synthesis (DOS) emerges as an excellent strategy that leads to a library of structurally complex and diverse small molecules, covering a larger chemical space and increasing the probability of identifying modulators.
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| Format: | Digital revista |
| Language: | Portuguese |
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Sociedade Brasileira de Química
2016
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422016000800995 |
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