Synthesis of 1H-benzoxazine-2,4-diones from heterocyclic anhydrides: evaluation of antioxidant and antimicrobial activities

Synthesis of 1H-benzoxazine-2,4-diones from heterocyclic anhydrides: evaluation of antioxidant and antimicrobial activities

A facile one-step synthesis of 1H-benzoxazine-2,4-diones from heterocyclic anhydrides and TMSA was described. This paper determines their antimicrobial activity against nine human bacterial pathogens by the broth microdilution method; antioxidant activity by DPPH• inactivation and a ferric-reducing power assay; and toxicity by a brine shrimp, Artemia salina, assay. The 1H-benzoxazine-2,4-dione yields were in the range of 57 to 98%. The novel compound 1H-pyrazino[2,3-][1,3]oxazine-2,4-dione 4c showed the highest antioxidant capacity (DPPH 35.4% and FRAP 0.063 µmol TEs/µmol).

Saved in:
Bibliographic Details
Main Authors: Sarmiento-Sánchez,Juan I., Montes-Avila,Julio, Ochoa-Terán,Adrián, Delgado-Vargas,Francisco, Wilson-Corral,Victor, Díaz-Camacho,Sylvia P., García-Páez,Fernando, Bastidas-Bastidas,Pedro
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2014
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000800006
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000800006

Similar Items