Desenvolvimento e validação de um método analítico por espectrofotometria UV para quantificação de carvedilol

This paper reports the development and validation of a new analytical method using UV spectrophotometry to quantify carvedilol (CRV) in hydrophilic matrices and raw material. This method was shown to be linear, accurate, precise, robust and to have adequate limits of quantification and detection (LQ and LD, respectively), allowing its use in the dissolution test of hydrophilic matrices. The content of CRV determined through this method was compared with two previously validated methods based on the reference techniques of High Performance Liquid Chromatography (HPLC) and Potentiometric Titrations (PT). ANOVA confirmed the equivalence of these methods, showing no significant differences.

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Bibliographic Details
Main Authors: Borba,Paola Aline Amarante, Riekes,Manoela Klüppel, Pereira,Rafael Nicolay, Stulzer,Hellen Karine, Vecchia,Debora Dalla
Format: Digital revista
Language:Portuguese
Published: Sociedade Brasileira de Química 2013
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000400017
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