Atividade anticolinesterásica e perfil químico de uma fração cromatográfica ativa do extrato etanólico das flores Bellis perennis L. (Asteraceae)

This work describes the isolation of an active flavonoid fraction and identification of isorhamnetin 3-O-β-D-(6''-acetyl)-galactopyranoside from flowers of B. perennis, and also the evaluation of anticholinesterase (AChE) activity of ethanolic extract from flowers (EEF) and the active fraction. The chemical structure of the flavonoid was defined on the basis of spectroscopic ¹H NMR, IR and UV data. EEF or flavonoid reduces AChE activity in vivo, while flavonoid also reduces AChE activity in vitro, showing a value of 1.49 mM for 50% inhibitory concentration (IC50), suggesting potential use as an insecticide or in the treatment of neurodegenerative diseases such as Alzheimer's disease.

Bibliographic Details

Main Authors:	Marques,Thiago Henrique Costa, Santos,Pauline Sousa dos, Freitas,Rivelilson Mendes de, Carvalho,Rusbene Bruno Fonseca de, Melo,Cassio Herbert Santos de, David,Juceni Pereira, David,Jorge Mauricio, Lima,Luciano Silva
Format:	Digital revista
Language:	Portuguese
Published:	Sociedade Brasileira de Química 2013
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000400012
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