Síntese, caracterização e estudo das propriedades de um novo complexo mononuclear contendo quercetina e íon Ga(III)

Flavonoids are one of the most important compound groups applied as medicine given their antioxidant properties, but several intrinsic properties can be improved through structural modifications to their molecules. Here, the synthesis and characterization of a new gallium (III) complex with quercetin is described. Electrochemical properties, as well as antioxidant and cytotoxic activities, were investigated and compared to the free flavonoid molecule. The mononuclear complex obtained, [Ga(C15H9O7)3].2H2O.2CH3OH.CH3CH2OH, seems more active as a DPPH radical scavenger given its lower oxidation potential compared to quercetin. The new complex cytotoxic responses have shown to be more effective than those of the free flavonoid and of lapachol used as a control.

Bibliographic Details

Main Authors:	Simões,Vanessa do Nascimento, Favarin,Lis Regiane Vizolli, Cabeza,Natália Aparecida, Oliveira,Tamires Donizeth de, Fiorucci,Antonio Rogério, Stropa,Jusinei Meireles, Rodrigues,Daniela Cristina Manfroi, Cavalheiro,Alberto Adriano, Anjos,Ademir dos
Format:	Digital revista
Language:	Portuguese
Published:	Sociedade Brasileira de Química 2013
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000400002
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