Aplysfistularine: a novel dibromotyrosine derivative isolated from Aplysina fistularis

The new dibromotyrosine derivative 3,5-dibromo-4-[3'dimethylamonium]propoxyphenyl]-N,N,N-trimethylethanamonium, here referred to as aplysfistularine (1), was isolated from the marine sponge Aplysina fistularis along with 2-(3,5-dibromo-4methoxyphenyl)-N,N,N-trimethylethanamonium (2), aplysterol (3) and 24,28-didehydroaplysterol (4). Their identification was performed by mass spectrometry, infrared, ¹H and 13C NMR, and by comparison with literature data. Compound 2 and the mixture of 3 and 4 were tested in vitro (inhibitory activity) with supercoiled DNA relaxation techniques, and showed inhibitory activity on human DNA topoisomerase II-α. Compound 1 was not tested due to paucity of the material.

Bibliographic Details

Main Authors:	Lira,Narlize Silva, Monte-Neto,Rubens L., Marchi,João Guilherme B., Lins,Antônio Cláudio da Silva, Tavares,Josean Fechine, Silva,Marcelo Sobral da, Dias,Celidarque da Silva, Barbosa-Filho,José Maria, Santos,Creusioni Figueredo dos, Cunha,Emídio Vasconcelos Leitão da, Pinheiro,Ulisses dos Santos, Braz-Filho,Raimundo
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2012
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100017
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