Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever

Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever

In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers., against Aedes aegypti, the main vector of dengue. The absolute configuration of these compounds was determined by circular dichroism (CD) spectra. The LC50 values of the compounds evaluated justify the potential of T. toxicaria as a new natural larvicide.

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Main Authors: Vasconcelos,Jackson Nunes e, Santiago,Gilvandete Maria Pinheiro, Lima,Jefferson Queiroz, Mafezoli,Jair, Lemos,Telma Leda Gomes de, Silva,Francisca Renata Lopes da, Lima,Mary Anne Sousa, Pimenta,Antônia Torres Ávila, Braz-Filho,Raimundo, Arriaga,Angela Martha Campos, Cesarin-Sobrinho,Dari
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2012
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600005
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spelling oai:scielo:S0100-404220120006000052012-07-25Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue feverVasconcelos,Jackson Nunes eSantiago,Gilvandete Maria PinheiroLima,Jefferson QueirozMafezoli,JairLemos,Telma Leda Gomes deSilva,Francisca Renata Lopes daLima,Mary Anne SousaPimenta,Antônia Torres ÁvilaBraz-Filho,RaimundoArriaga,Angela Martha CamposCesarin-Sobrinho,Dari Tephrosia toxicaria rotenoids Aedes aegypti In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers., against Aedes aegypti, the main vector of dengue. The absolute configuration of these compounds was determined by circular dichroism (CD) spectra. The LC50 values of the compounds evaluated justify the potential of T. toxicaria as a new natural larvicide.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.35 n.6 20122012-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600005en10.1590/S0100-40422012000600005
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Vasconcelos,Jackson Nunes e
Santiago,Gilvandete Maria Pinheiro
Lima,Jefferson Queiroz
Mafezoli,Jair
Lemos,Telma Leda Gomes de
Silva,Francisca Renata Lopes da
Lima,Mary Anne Sousa
Pimenta,Antônia Torres Ávila
Braz-Filho,Raimundo
Arriaga,Angela Martha Campos
Cesarin-Sobrinho,Dari
spellingShingle Vasconcelos,Jackson Nunes e
Santiago,Gilvandete Maria Pinheiro
Lima,Jefferson Queiroz
Mafezoli,Jair
Lemos,Telma Leda Gomes de
Silva,Francisca Renata Lopes da
Lima,Mary Anne Sousa
Pimenta,Antônia Torres Ávila
Braz-Filho,Raimundo
Arriaga,Angela Martha Campos
Cesarin-Sobrinho,Dari
Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever
author_facet Vasconcelos,Jackson Nunes e
Santiago,Gilvandete Maria Pinheiro
Lima,Jefferson Queiroz
Mafezoli,Jair
Lemos,Telma Leda Gomes de
Silva,Francisca Renata Lopes da
Lima,Mary Anne Sousa
Pimenta,Antônia Torres Ávila
Braz-Filho,Raimundo
Arriaga,Angela Martha Campos
Cesarin-Sobrinho,Dari
author_sort Vasconcelos,Jackson Nunes e
title Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever
title_short Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever
title_full Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever
title_fullStr Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever
title_full_unstemmed Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever
title_sort rotenoids from tephrosia toxicaria with larvicidal activity against aedes aegypti, the main vector of dengue fever
description In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers., against Aedes aegypti, the main vector of dengue. The absolute configuration of these compounds was determined by circular dichroism (CD) spectra. The LC50 values of the compounds evaluated justify the potential of T. toxicaria as a new natural larvicide.
publisher Sociedade Brasileira de Química
publishDate 2012
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600005
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