Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever
In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers., against Aedes aegypti, the main vector of dengue. The absolute configuration of these compounds was determined by circular dichroism (CD) spectra. The LC50 values of the compounds evaluated justify the potential of T. toxicaria as a new natural larvicide.
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Sociedade Brasileira de Química
2012
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oai:scielo:S0100-404220120006000052012-07-25Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue feverVasconcelos,Jackson Nunes eSantiago,Gilvandete Maria PinheiroLima,Jefferson QueirozMafezoli,JairLemos,Telma Leda Gomes deSilva,Francisca Renata Lopes daLima,Mary Anne SousaPimenta,Antônia Torres ÁvilaBraz-Filho,RaimundoArriaga,Angela Martha CamposCesarin-Sobrinho,Dari Tephrosia toxicaria rotenoids Aedes aegypti In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers., against Aedes aegypti, the main vector of dengue. The absolute configuration of these compounds was determined by circular dichroism (CD) spectra. The LC50 values of the compounds evaluated justify the potential of T. toxicaria as a new natural larvicide.info:eu-repo/semantics/openAccessSociedade Brasileira de QuímicaQuímica Nova v.35 n.6 20122012-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600005en10.1590/S0100-40422012000600005 |
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Vasconcelos,Jackson Nunes e Santiago,Gilvandete Maria Pinheiro Lima,Jefferson Queiroz Mafezoli,Jair Lemos,Telma Leda Gomes de Silva,Francisca Renata Lopes da Lima,Mary Anne Sousa Pimenta,Antônia Torres Ávila Braz-Filho,Raimundo Arriaga,Angela Martha Campos Cesarin-Sobrinho,Dari |
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Vasconcelos,Jackson Nunes e Santiago,Gilvandete Maria Pinheiro Lima,Jefferson Queiroz Mafezoli,Jair Lemos,Telma Leda Gomes de Silva,Francisca Renata Lopes da Lima,Mary Anne Sousa Pimenta,Antônia Torres Ávila Braz-Filho,Raimundo Arriaga,Angela Martha Campos Cesarin-Sobrinho,Dari Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever |
author_facet |
Vasconcelos,Jackson Nunes e Santiago,Gilvandete Maria Pinheiro Lima,Jefferson Queiroz Mafezoli,Jair Lemos,Telma Leda Gomes de Silva,Francisca Renata Lopes da Lima,Mary Anne Sousa Pimenta,Antônia Torres Ávila Braz-Filho,Raimundo Arriaga,Angela Martha Campos Cesarin-Sobrinho,Dari |
author_sort |
Vasconcelos,Jackson Nunes e |
title |
Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever |
title_short |
Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever |
title_full |
Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever |
title_fullStr |
Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever |
title_full_unstemmed |
Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever |
title_sort |
rotenoids from tephrosia toxicaria with larvicidal activity against aedes aegypti, the main vector of dengue fever |
description |
In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers., against Aedes aegypti, the main vector of dengue. The absolute configuration of these compounds was determined by circular dichroism (CD) spectra. The LC50 values of the compounds evaluated justify the potential of T. toxicaria as a new natural larvicide. |
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Sociedade Brasileira de Química |
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2012 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600005 |
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