Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever

Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever

In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers., against Aedes aegypti, the main vector of dengue. The absolute configuration of these compounds was determined by circular dichroism (CD) spectra. The LC50 values of the compounds evaluated justify the potential of T. toxicaria as a new natural larvicide.

Saved in:
Bibliographic Details
Main Authors: Vasconcelos,Jackson Nunes e, Santiago,Gilvandete Maria Pinheiro, Lima,Jefferson Queiroz, Mafezoli,Jair, Lemos,Telma Leda Gomes de, Silva,Francisca Renata Lopes da, Lima,Mary Anne Sousa, Pimenta,Antônia Torres Ávila, Braz-Filho,Raimundo, Arriaga,Angela Martha Campos, Cesarin-Sobrinho,Dari
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2012
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600005
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000600005

Similar Items