Characterization and in vitro release of cyclosporine-A from poly(D,L-lactide-co-glycolide implants obtained by solvent/extraction evaporation

Cyclosporine-A-loaded PLGA implants were developed intended for ocular route. Implants were prepared using solvent extraction/evaporation technique followed by casting of the cake into rods in a heated surface. XRD patterns showed that cyclosporine-A was completely incorporated into PLGA. FTIR and DSC results indicated alterations on drug molecular conformation aiming to reach the most stable thermodynamic conformation at polymer/drug interface. Implants provided controlled/sustained in vitro release of the drug. During the first 7 weeks, the drug release was controlled by the diffusion of the cyclosporine-A; and between 7-23 week period, the drug diffusion and degradation of PLGA controlled the drug release.

Bibliographic Details

Main Authors:	Saliba,Juliana Barbosa, Silva-Cunha Junior,Armando da, Silva,Gisele Rodrigues da, Yoshida,Maria Irene, Mansur,Alexandra Ancelmo Piscitelli, Mansur,Herman Sander
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Química 2012
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000400013
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