Anxiolytic-like effects of erythrinian alkaloids from erythrina suberosa

Anxiolytic-like effects of erythrinian alkaloids from erythrina suberosa

Two alkaloids, erysodine (1) and erysothrine (2) were isolated from the flowers of a Pakistani medicinal plant, Erythrina suberosa. These compounds were investigated for anxiolytic properties, and the results showed significant effect, in an acute oral treatment with 1-2, which were suspended in saline (NaCl 0.9%) plus DMSO 1%, and evaluated in 122 Swiss male mice exposed to two tests of anxiety - the elevated plus-maze (EPM) and the light/dark transition model (LDTM).

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Bibliographic Details
Main Authors: Serrano,Maria Amélia Rodrigues, Batista,Andrea Nastri de Luca, Bolzani,Vanderlan da Silva, Santos,Luciana de Ávila, Nogueira,Paulo José de Campos, Nunes-de-Souza,Ricardo Luiz, Latif,Abdul, Arfan,Mohammad
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Química 2011
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000500015
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