Coordenação de metais a antibióticos como uma estratégia de combate à resistência bacteriana

Antibiotic resistance has been growing at an alarming rate and consequently the arsenal of effective antibiotics against Gram-negative and Gram-positive bacteria has dropped dramatically. In this sense there is a strong need to produce new substances that not only have good spectrum of activity, but having new mechanisms of action. In this regard, this paper emphasizes the coordination of metals to antibiotics as a strategy for reversing antibiotic resistance and production of new drugs, with a special focus on quinolones, fluoroquinolones, sulfonamides and tetracyclines.

Bibliographic Details

Main Authors:	Rocha,Diego Pessoa, Pinto,Gabriel Ferreira, Ruggiero,Reinaldo, Oliveira,Carlos Alberto de, Guerra,Wendell, Fontes,Ana Paula Soares, Tavares,Tatiane Teixeira, Marzano,Ivana Marques, Pereira-Maia,Elene Cristina
Format:	Digital revista
Language:	Portuguese
Published:	Sociedade Brasileira de Química 2011
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000100022
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