Síntese e avaliação preliminar da atividade antinociceptiva de novas isoxazolil-aril-hidrazonas

Síntese e avaliação preliminar da atividade antinociceptiva de novas isoxazolil-aril-hidrazonas

New 2-isoxazoline aldehydes were synthesized, in good yields, from cycloadduct of the 1,3-dipolar cycloaddition reaction between endocyclic enecarbamate and carboethoxyformonitrile oxide (CEFNO). Condensation of these 2-isoxazoline aldehydes with several phenyl-hydrazines produced new isoxazolyl-aryl-hydrazones, which showed low toxicity and excellent antinociceptive activity, when compared to dipyrone. The antinociceptive activity of isoxazolyl-aryl-hydrazones was performed using the acetic acid-induced mice abdominal constrictions test.

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Bibliographic Details
Main Authors: Reis,Sílvio Leandro Gonçalves Bomfim, Almeida,Valderes Moraes de, Almeida,Gleybson Correia de, Boaviagem,Karinna Moura, Mendes,Charles Christophe Du Barriere, Faria,Antônio Rodolfo de, Góes,Alexandre José da Silva, Magalhães,Laudelina Rodrigues, Silva,Teresinha Gonçalves da
Format: Digital revista
Language:Portuguese
Published: Sociedade Brasileira de Química 2011
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422011000100015
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