Utilização de RMN de ¹H na determinação da configuração absoluta de álcoois
This review reports the determination of absolute configuration of primary and secondary alcohols by ¹H NMR spectroscopy, using the Mosher method. This method consists in the derivatization of an alcohol possessig unknown absolute configuration with one or both enantiomers of an auxiliary reagent. The resulting diastereoisomer spectra are registered and compared, and the chemical shift differences (<FONT FACE=Symbol>Dd</FONT>R,S = deltaR - deltaS) are measured. The determination of the absolute configuration of the alcohol molecule is based on the correlation between its chiral center and the auxiliary reagent's chiral center. Therefore, the determination of the absolute configuration depends on aromatic ring shielding effects on the substituents of the alcohol as evidenced by the ¹H NMR spectrum.
| Main Authors: | , , |
|---|---|
| Format: | Digital revista |
| Language: | Portuguese |
| Published: |
Sociedade Brasileira de Química
2005
|
| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422005000600022 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|