Seleção de plantas com atividade anticolinasterase para tratamento da doença de Alzheimer
Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognite impairment and personality changes. The development of drugs for the treatment of the cognitive deficits of AD has focused on agents which counteract loss in cholinergic activities. These symptons of AD have been successfully treated with acetylcholinesterase (AchE) inhibitors (eg. galanthamine). There still is great interest in finding better AchE inhibitors. We use Ellmann's microplate assay and silica gel thin-layer chromatography (TLC) to screen natural products from plants as new sources of AchE inhibitors.
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Digital revista |
| Language: | Portuguese |
| Published: |
Sociedade Brasileira de Química
2003
|
| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000300002 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|