Terapia fotodinâmica: aspectos farmacológicos, aplicações e avanços recentes no desenvolvimento de medicamentos
Photodynamic Therapy (PDT) is a clinical procedure, which utilize a photosensitive compound and light. This is a new modality of treatment for cancer, aged related macular degenerescence (AMD), psoriasis, arthritis, arterial restenosis, etc which exhibits efficiency, less traumatic effects, low recovery time and few co-lateral effects. The first officially approved drug for PDT by the Food and Drug Administration (EUA) is Photofrin<FONT FACE=Symbol>â</FONT>, which is applied for cancer. A new generation drug for PDT, Visudyne<FONT FACE=Symbol>â</FONT> was recently approved to treat AMD; its photoactive compound is BPDMA, a benzoporphyrin mono-acid derivative (chlorin-type molecule). A concise history, technical information and some drugs for PDT are reported.
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Format: | Digital revista |
Language: | Portuguese |
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Sociedade Brasileira de Química
2002
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Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000500016 |
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