Reações de ortometalacão em piridinas
In this paper we describe a powerful methodology for the regiospecific construction of polysubstituted aromatic and heteroaromatic compounds. The DoM reaction (direct ortho-metalation) comprises the deprotonation in position ortho of a aromatic or heteroaromatic containing DMG (directed metalation group) by strong bases, normally an alkyllithium reagent, leading to an ortho-lithiated species. These species, upon treatment with electrophilic reagents, gives 1,2 disubstituted products.
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Digital revista |
| Language: | Portuguese |
| Published: |
Sociedade Brasileira de Química
2002
|
| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422002000100016 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|