Host cholesterol influences the activity of sterol biosynthesis inhibitors in Leishmania amazonensis

A significant percentage of exogenous cholesterol was found in promastigotes and amastigotes of all studied species of Leishmania, suggesting a biological role for this molecule. Previous studies have shown that promastigotes of Leishmania uptake more low-density lipoprotein (LDL) particles under pharmacological pressure and are more susceptible to ergosterol inhibition in the absence of exogenous sources of cholesterol. This work shows that the host’s LDL is available to intracellular amastigotes and that the absence of exogenous cholesterol enhances the potency of sterol biosynthesis inhibitors in infected macrophages. A complete understanding of cholesterol transport to the parasitophorous vacuole can guide the development of a new drug class to be used in combination with sterol biosynthesis inhibitors for the treatment of leishmaniases.

Bibliographic Details

Main Authors:	Andrade-Neto,Valter Viana, Manso,Pedro Paulo de Abreu, Pereira,Miria Gomes, de Cicco,Nuccia Nicole Theodoro, Atella,Georgia Corrêa, Pelajo-Machado,Marcelo, Menna-Barreto,Rubem Figueiredo Sadok, Torres-Santos,Eduardo Caio
Format:	Digital revista
Language:	English
Published:	Instituto Oswaldo Cruz, Ministério da Saúde 2022
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762022000100862
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