In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures

In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures

We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytotoxicity tests against L929 cells, only compound 4 presented selectivity index value above 10, indicating low toxicity.

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Bibliographic Details
Main Authors: Lavorato,Stefânia Neiva, Sales Júnior,Policarpo Ademar, Murta,Silvane Maria Fonseca, Romanha,Alvaro José, Alves/,Ricardo José
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2015
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000400566
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