The use of halloysite clay and carboxyl-functionalised multi-walled carbon nanotubes for recombinant LipL32 antigen delivery enhanced the IgG response

We studied the feasibility of using halloysite clay nanotubes (HNTs) and carboxyl-functionalised multi-walled carbon nanotubes (COOH-MWCNTs) as antigen carriers to improve immune responses against a recombinant LipL32 protein (rLipL32). Immunisation using the HNTs or COOH-MWCNTs significantly increased the rLipL32-specific IgG antibody titres (p < 0.05) of Golden Syrian hamsters. None of the vaccines tested conferred protection against a challenge using a virulent Leptospira interrogans strain. These results demonstrated that nanotubes can be used as antigen carriers for delivery in hosts and the induction of a humoral immune response against purified leptospiral antigens used in subunit vaccine preparations.

Bibliographic Details

Main Authors:	Hartwig,Daiane D, Bacelo,Kátia L, Oliveira,Thaís L, Schuch,Rodrigo, Seixas,Fabiana K, Collares,Tiago, Rodrigues,Oscar, Hartleben,Cláudia P, Dellagostin,Odir A
Format:	Digital revista
Language:	English
Published:	Instituto Oswaldo Cruz, Ministério da Saúde 2015
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000100134
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