Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela
An in-house, low-cost method was developed to determine the genotypic resistance of immunodeficiency virus type 1 (HIV-1) isolates. All 179 Venezuelan isolates analysed belonged to subtype B. Primary drug resistance mutations were found in 11% of 63 treatment-naïve patients. The prevalence of resistance in isolates from 116 HIV-positive patients under antiretroviral treatment was 47% to protease inhibitors, 65% to nucleoside inhibitors and 38% to non-nucleoside inhibitors, respectively. Around 50% of patients in the study harboured viruses with highly reduced susceptibility to the three classical types of drugs after only five years from their initial diagnoses.
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Instituto Oswaldo Cruz, Ministério da Saúde
2009
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oai:scielo:S0074-027620090003000202009-06-09Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in VenezuelaRangel,Héctor RafaelGarzaro,Domingo JoséTorres,Jaime RafaelCastro,JulioSuarez,Jose AntonioNaranjo,LauraOssenkopp,JohnMartinez,NahírGutierrez,CristinaPujol,Flor Helene HIV genotypic resistance diagnostic Venezuela An in-house, low-cost method was developed to determine the genotypic resistance of immunodeficiency virus type 1 (HIV-1) isolates. All 179 Venezuelan isolates analysed belonged to subtype B. Primary drug resistance mutations were found in 11% of 63 treatment-naïve patients. The prevalence of resistance in isolates from 116 HIV-positive patients under antiretroviral treatment was 47% to protease inhibitors, 65% to nucleoside inhibitors and 38% to non-nucleoside inhibitors, respectively. Around 50% of patients in the study harboured viruses with highly reduced susceptibility to the three classical types of drugs after only five years from their initial diagnoses.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.104 n.3 20092009-05-01info:eu-repo/semantics/othertext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300020en10.1590/S0074-02762009000300020 |
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Rangel,Héctor Rafael Garzaro,Domingo José Torres,Jaime Rafael Castro,Julio Suarez,Jose Antonio Naranjo,Laura Ossenkopp,John Martinez,Nahír Gutierrez,Cristina Pujol,Flor Helene |
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Rangel,Héctor Rafael Garzaro,Domingo José Torres,Jaime Rafael Castro,Julio Suarez,Jose Antonio Naranjo,Laura Ossenkopp,John Martinez,Nahír Gutierrez,Cristina Pujol,Flor Helene Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela |
author_facet |
Rangel,Héctor Rafael Garzaro,Domingo José Torres,Jaime Rafael Castro,Julio Suarez,Jose Antonio Naranjo,Laura Ossenkopp,John Martinez,Nahír Gutierrez,Cristina Pujol,Flor Helene |
author_sort |
Rangel,Héctor Rafael |
title |
Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela |
title_short |
Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela |
title_full |
Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela |
title_fullStr |
Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela |
title_full_unstemmed |
Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela |
title_sort |
prevalence of antiretroviral drug resistance among treatment-naive and treated hiv-infected patients in venezuela |
description |
An in-house, low-cost method was developed to determine the genotypic resistance of immunodeficiency virus type 1 (HIV-1) isolates. All 179 Venezuelan isolates analysed belonged to subtype B. Primary drug resistance mutations were found in 11% of 63 treatment-naïve patients. The prevalence of resistance in isolates from 116 HIV-positive patients under antiretroviral treatment was 47% to protease inhibitors, 65% to nucleoside inhibitors and 38% to non-nucleoside inhibitors, respectively. Around 50% of patients in the study harboured viruses with highly reduced susceptibility to the three classical types of drugs after only five years from their initial diagnoses. |
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Instituto Oswaldo Cruz, Ministério da Saúde |
publishDate |
2009 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300020 |
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