Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela

Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela

An in-house, low-cost method was developed to determine the genotypic resistance of immunodeficiency virus type 1 (HIV-1) isolates. All 179 Venezuelan isolates analysed belonged to subtype B. Primary drug resistance mutations were found in 11% of 63 treatment-naïve patients. The prevalence of resistance in isolates from 116 HIV-positive patients under antiretroviral treatment was 47% to protease inhibitors, 65% to nucleoside inhibitors and 38% to non-nucleoside inhibitors, respectively. Around 50% of patients in the study harboured viruses with highly reduced susceptibility to the three classical types of drugs after only five years from their initial diagnoses.

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Main Authors: Rangel,Héctor Rafael, Garzaro,Domingo José, Torres,Jaime Rafael, Castro,Julio, Suarez,Jose Antonio, Naranjo,Laura, Ossenkopp,John, Martinez,Nahír, Gutierrez,Cristina, Pujol,Flor Helene
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2009
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300020
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spelling oai:scielo:S0074-027620090003000202009-06-09Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in VenezuelaRangel,Héctor RafaelGarzaro,Domingo JoséTorres,Jaime RafaelCastro,JulioSuarez,Jose AntonioNaranjo,LauraOssenkopp,JohnMartinez,NahírGutierrez,CristinaPujol,Flor Helene HIV genotypic resistance diagnostic Venezuela An in-house, low-cost method was developed to determine the genotypic resistance of immunodeficiency virus type 1 (HIV-1) isolates. All 179 Venezuelan isolates analysed belonged to subtype B. Primary drug resistance mutations were found in 11% of 63 treatment-naïve patients. The prevalence of resistance in isolates from 116 HIV-positive patients under antiretroviral treatment was 47% to protease inhibitors, 65% to nucleoside inhibitors and 38% to non-nucleoside inhibitors, respectively. Around 50% of patients in the study harboured viruses with highly reduced susceptibility to the three classical types of drugs after only five years from their initial diagnoses.info:eu-repo/semantics/openAccessInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz v.104 n.3 20092009-05-01info:eu-repo/semantics/othertext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300020en10.1590/S0074-02762009000300020
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country Brasil
countrycode BR
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region America del Sur
libraryname SciELO
language English
format Digital
author Rangel,Héctor Rafael
Garzaro,Domingo José
Torres,Jaime Rafael
Castro,Julio
Suarez,Jose Antonio
Naranjo,Laura
Ossenkopp,John
Martinez,Nahír
Gutierrez,Cristina
Pujol,Flor Helene
spellingShingle Rangel,Héctor Rafael
Garzaro,Domingo José
Torres,Jaime Rafael
Castro,Julio
Suarez,Jose Antonio
Naranjo,Laura
Ossenkopp,John
Martinez,Nahír
Gutierrez,Cristina
Pujol,Flor Helene
Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela
author_facet Rangel,Héctor Rafael
Garzaro,Domingo José
Torres,Jaime Rafael
Castro,Julio
Suarez,Jose Antonio
Naranjo,Laura
Ossenkopp,John
Martinez,Nahír
Gutierrez,Cristina
Pujol,Flor Helene
author_sort Rangel,Héctor Rafael
title Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela
title_short Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela
title_full Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela
title_fullStr Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela
title_full_unstemmed Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela
title_sort prevalence of antiretroviral drug resistance among treatment-naive and treated hiv-infected patients in venezuela
description An in-house, low-cost method was developed to determine the genotypic resistance of immunodeficiency virus type 1 (HIV-1) isolates. All 179 Venezuelan isolates analysed belonged to subtype B. Primary drug resistance mutations were found in 11% of 63 treatment-naïve patients. The prevalence of resistance in isolates from 116 HIV-positive patients under antiretroviral treatment was 47% to protease inhibitors, 65% to nucleoside inhibitors and 38% to non-nucleoside inhibitors, respectively. Around 50% of patients in the study harboured viruses with highly reduced susceptibility to the three classical types of drugs after only five years from their initial diagnoses.
publisher Instituto Oswaldo Cruz, Ministério da Saúde
publishDate 2009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300020
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