Prevalence of antiretroviral drug resistance among treatment-naive and treated HIV-infected patients in Venezuela

An in-house, low-cost method was developed to determine the genotypic resistance of immunodeficiency virus type 1 (HIV-1) isolates. All 179 Venezuelan isolates analysed belonged to subtype B. Primary drug resistance mutations were found in 11% of 63 treatment-naïve patients. The prevalence of resistance in isolates from 116 HIV-positive patients under antiretroviral treatment was 47% to protease inhibitors, 65% to nucleoside inhibitors and 38% to non-nucleoside inhibitors, respectively. Around 50% of patients in the study harboured viruses with highly reduced susceptibility to the three classical types of drugs after only five years from their initial diagnoses.

Bibliographic Details

Main Authors:	Rangel,Héctor Rafael, Garzaro,Domingo José, Torres,Jaime Rafael, Castro,Julio, Suarez,Jose Antonio, Naranjo,Laura, Ossenkopp,John, Martinez,Nahír, Gutierrez,Cristina, Pujol,Flor Helene
Format:	Digital revista
Language:	English
Published:	Instituto Oswaldo Cruz, Ministério da Saúde 2009
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762009000300020
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