In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe

In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe

This paper reports the overall effects of three lectins, extracted from Canavalia brasiliensis, Dioclea violacea, and D. grandiflora, on BALB/c mice popliteal draining lymph nodes. These lectins have presented high stimulatory capacity on lymph node T cells. Additionally, they were able to induce apoptosis and inflammation (frequently associated with high endothelial venule necrosis). The data presented here suggest that the Diocleinae lectins studied can stimulate in vivo T cell activation and apoptosis, as well as present important side effects.

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Bibliographic Details
Main Authors: Barbosa,Theolis, Arruda,Sérgio, Cavada,Benildo, Grangeiro,Thalles Barbosa, Freitas,Luiz Antônio Rodrigues de, Barral-Netto,Manoel
Format: Digital revista
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2001
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000500016
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000500016

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