Typing and susceptibility to penicillin of Neisseria meningitidis isolated from patients in Cuba (1993-1999)

The susceptibility to penicillin of 111 Neisseria meningitidis strains was assessed by the agar-dilution procedure and serosubtypes were determined by a whole-cell enzyme-linked immunoassay using monoclonal antibodies reagents. Thirty-five isolates showed reduced sensitivity to penicillin (MIC > or = 0.1 mg/l and <= 1 mg/l) and no resistant strains were detected. The most common phenotype was B:4:P1.15 (77.5%) and a rising trend of non-typeable and non-subtypeable strains was detected. The increase in levels of minimal inhibitory concentrations of meningococci to penicillin gives cause for concern and the increase in non-typeable and non-subtypeable isolation demand the use of molecular biology techniques for their typing.

Bibliographic Details

Main Authors:	Sosa,Jorge, Llanes,Rafael, Guzmán,Daymi, Quintana,Ibrahín, Flores,Mayra, Gutiérrez,Oderay
Format:	Digital revista
Language:	English
Published:	Instituto Oswaldo Cruz, Ministério da Saúde 2001
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762001000400014
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