Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study

ABSTRACT Background: Although primaquine (PQ) is indicated for G6PD-deficient patients, data on weekly PQ use in Brazil are limited. Methods: We aimed to investigate malaria recurrences among participants receiving daily and weekly PQ treatments in a real-life setting of two municipalities in the Amazon between 2019 and 2020. Results: Patients receiving weekly PQ treatment had a lower risk of recurrence than those receiving daily PQ treatment (risk ratio: 0.62, 95% confidence interval: 0.41-0.94), using a model adjusted for study site. Conclusions: Weekly PQ use did not increase the risk of malaria recurrence. Further studies with larger populations are warranted.

Bibliographic Details

Main Authors:	Brito-Sousa,Jose Diego, Phanor,Jeffe, Balieiro,Patricia Carvalho da Silva, Silva-Neto,Alexandre Vilhena, Cordeiro,Jady Shayenne Mota, Vitor-Silva,Sheila, Mendes,Maxwell, Sampaio,Vanderson Souza, Melo,Gisely Cardoso de, Lacerda,Marcus, Monteiro,Wuelton
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2022
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822022000100613
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