Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil

Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil

Abstract INTRODUCTION: In Brazil, West Nile virus (WNV) was first detected, in 2018, in horses with neurological disease. AIM: We report the first case of WNV infection in a horse from Ceará state and the complete genome sequence of an isolate from Espírito Santo state. Both infections occurred in 2019. METHODS: WNV was isolated from the tissues of a horse with neurological signs in Espírito Santo and sequenced by MiSeq. RESULTS: Phylogenetic analysis revealed that the isolate belongs to lineage 1a, clustering with the NY99 strain, a strain that has not circulated in the USA since 2005. CONCLUSIONS: Our findings reinforce the hypothesis that WNV has been silently circulating in Brazil for many years.

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Main Authors: Siconelli,Márcio Junio Lima, Jorge,Daniel Macedo de Melo, Castro-Jorge,Luiza Antunes de, Fonseca-Júnior,Antônio Augusto, Nascimento,Mateus Laguardia, Floriano,Vitor Gonçalves, Souza,Fransérgio Rocha de, Queiroz-Júnior,Eudson Maia de, Camargos,Marcelo Fernandes, Costa,Eliana Dea Lara, Carvalho,Adolorata Aparecida Bianco, Fonseca,Benedito Antonio Lopes da
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Medicina Tropical - SBMT 2021
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100630
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spelling oai:scielo:S0037-868220210001006302021-03-04Evidence for current circulation of an ancient West Nile virus strain (NY99) in BrazilSiconelli,Márcio Junio LimaJorge,Daniel Macedo de MeloCastro-Jorge,Luiza Antunes deFonseca-Júnior,Antônio AugustoNascimento,Mateus LaguardiaFloriano,Vitor GonçalvesSouza,Fransérgio Rocha deQueiroz-Júnior,Eudson Maia deCamargos,Marcelo FernandesCosta,Eliana Dea LaraCarvalho,Adolorata Aparecida BiancoFonseca,Benedito Antonio Lopes da West nile virus NY99 strain Horses Abstract INTRODUCTION: In Brazil, West Nile virus (WNV) was first detected, in 2018, in horses with neurological disease. AIM: We report the first case of WNV infection in a horse from Ceará state and the complete genome sequence of an isolate from Espírito Santo state. Both infections occurred in 2019. METHODS: WNV was isolated from the tissues of a horse with neurological signs in Espírito Santo and sequenced by MiSeq. RESULTS: Phylogenetic analysis revealed that the isolate belongs to lineage 1a, clustering with the NY99 strain, a strain that has not circulated in the USA since 2005. CONCLUSIONS: Our findings reinforce the hypothesis that WNV has been silently circulating in Brazil for many years.info:eu-repo/semantics/openAccessSociedade Brasileira de Medicina Tropical - SBMTRevista da Sociedade Brasileira de Medicina Tropical v.54 20212021-01-01info:eu-repo/semantics/othertext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100630en10.1590/0037-8682-0687-2020
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country Brasil
countrycode BR
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region America del Sur
libraryname SciELO
language English
format Digital
author Siconelli,Márcio Junio Lima
Jorge,Daniel Macedo de Melo
Castro-Jorge,Luiza Antunes de
Fonseca-Júnior,Antônio Augusto
Nascimento,Mateus Laguardia
Floriano,Vitor Gonçalves
Souza,Fransérgio Rocha de
Queiroz-Júnior,Eudson Maia de
Camargos,Marcelo Fernandes
Costa,Eliana Dea Lara
Carvalho,Adolorata Aparecida Bianco
Fonseca,Benedito Antonio Lopes da
spellingShingle Siconelli,Márcio Junio Lima
Jorge,Daniel Macedo de Melo
Castro-Jorge,Luiza Antunes de
Fonseca-Júnior,Antônio Augusto
Nascimento,Mateus Laguardia
Floriano,Vitor Gonçalves
Souza,Fransérgio Rocha de
Queiroz-Júnior,Eudson Maia de
Camargos,Marcelo Fernandes
Costa,Eliana Dea Lara
Carvalho,Adolorata Aparecida Bianco
Fonseca,Benedito Antonio Lopes da
Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
author_facet Siconelli,Márcio Junio Lima
Jorge,Daniel Macedo de Melo
Castro-Jorge,Luiza Antunes de
Fonseca-Júnior,Antônio Augusto
Nascimento,Mateus Laguardia
Floriano,Vitor Gonçalves
Souza,Fransérgio Rocha de
Queiroz-Júnior,Eudson Maia de
Camargos,Marcelo Fernandes
Costa,Eliana Dea Lara
Carvalho,Adolorata Aparecida Bianco
Fonseca,Benedito Antonio Lopes da
author_sort Siconelli,Márcio Junio Lima
title Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
title_short Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
title_full Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
title_fullStr Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
title_full_unstemmed Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil
title_sort evidence for current circulation of an ancient west nile virus strain (ny99) in brazil
description Abstract INTRODUCTION: In Brazil, West Nile virus (WNV) was first detected, in 2018, in horses with neurological disease. AIM: We report the first case of WNV infection in a horse from Ceará state and the complete genome sequence of an isolate from Espírito Santo state. Both infections occurred in 2019. METHODS: WNV was isolated from the tissues of a horse with neurological signs in Espírito Santo and sequenced by MiSeq. RESULTS: Phylogenetic analysis revealed that the isolate belongs to lineage 1a, clustering with the NY99 strain, a strain that has not circulated in the USA since 2005. CONCLUSIONS: Our findings reinforce the hypothesis that WNV has been silently circulating in Brazil for many years.
publisher Sociedade Brasileira de Medicina Tropical - SBMT
publishDate 2021
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100630
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