Evidence for current circulation of an ancient West Nile virus strain (NY99) in Brazil

Abstract INTRODUCTION: In Brazil, West Nile virus (WNV) was first detected, in 2018, in horses with neurological disease. AIM: We report the first case of WNV infection in a horse from Ceará state and the complete genome sequence of an isolate from Espírito Santo state. Both infections occurred in 2019. METHODS: WNV was isolated from the tissues of a horse with neurological signs in Espírito Santo and sequenced by MiSeq. RESULTS: Phylogenetic analysis revealed that the isolate belongs to lineage 1a, clustering with the NY99 strain, a strain that has not circulated in the USA since 2005. CONCLUSIONS: Our findings reinforce the hypothesis that WNV has been silently circulating in Brazil for many years.

Bibliographic Details

Main Authors:	Siconelli,Márcio Junio Lima, Jorge,Daniel Macedo de Melo, Castro-Jorge,Luiza Antunes de, Fonseca-Júnior,Antônio Augusto, Nascimento,Mateus Laguardia, Floriano,Vitor Gonçalves, Souza,Fransérgio Rocha de, Queiroz-Júnior,Eudson Maia de, Camargos,Marcelo Fernandes, Costa,Eliana Dea Lara, Carvalho,Adolorata Aparecida Bianco, Fonseca,Benedito Antonio Lopes da
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2021
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100630
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