Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management

Confirmed Invasive Pulmonary Aspergillosis and COVID-19: the value of postmortem findings to support antemortem management

Abstract We present postmortem evidence of invasive pulmonary aspergillosis (IPA) in a patient with severe COVID-19. Autopsies of COVID-19 confirmed cases were performed. The patient died despite antimicrobials, mechanical ventilation, and vasopressor support. Histopathology and peripheral blood galactomannan antigen testing confirmed IPA. Aspergillus penicillioides infection was confirmed by nucleotide sequencing and BLAST analysis. Further reports are needed to assess the occurrence and frequency of IPA in SARS-CoV-2 infections, and how they interact clinically.

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Bibliographic Details
Main Authors: Santana,Monique Freire, Pivoto,Guilherme, Alexandre,Márcia A. Araujo, Baía-da-Silva,Djane Clarys, Borba,Mayla Gabriela da Silva, Val,Fernando Almeida, Brito-Sousa,Jose Diego, Melo,Gisely Cardoso, Monteiro,Wuelton Marcelo, Souza,João Vicente Braga, Pinheiro,Silviane Bezerra, Ferreira,Luiz Carlos Lima, Naveca,Felipe Gomes, Nascimento,Valdinete Alves, Corado,André Lima Guerra, Hajjar,Ludhmila Abrahão, Silva Neto,João Ricardo, Siva,George Alan Villarouco, Pasqualotto,Alessandro C., Lacerda,Marcus Vinícius Guimarães
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Medicina Tropical - SBMT 2020
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100719
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