Adverse drug events and the associated factors in patients with chronic Chagas disease

Abstract INTRODUCTION: Herein, we aimed to identify the factors associated with adverse drug events (ADEs) in chronic Chagas disease (CD) patients. METHODS: We analyzed 320 medical notes from 295 patients. The Naranjo algorithm was applied to determine the cause of ADEs. Mixed effects logistic regression was performed to evaluate the factors associated with ADEs. RESULTS: ADEs were described in 102 medical notes (31.9%). Captopril was most frequently associated with ADEs. Age (RR 0.96; 95%CI 0.94-0.99) and cardiac C/D stages (RR 3.24; 95%CI 1.30-4.58) were the most important clinical factors associated with ADEs. CONCLUSIONS: Close follow-up is warranted for CD patients.

Bibliographic Details

Main Authors:	Lopes,Luiza Braz da Cunha, Pereira,Raquel Rodrigues, Andrade,Patricia Mello, Carneiro,Fernanda Martins, Mediano,Mauro Felippe Felix, Kilgore,Sophia Isabel Linnemann, Hasslocher-Moreno,Alejandro Marcel, Sousa,Andréa Silvestre de, Oliveira,Manoel Marques Evangelista, Saraiva,Roberto Magalhães, Holanda,Marcelo Teixeira de, Silva,Gilberto Marcelo Sperandio da
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2020
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822020000100639
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