Epidemiological and TNFα polymorphism evaluation in patients with cryptococcal meningitis treated at a referral hospital in North Brazil

Abstract INTRODUCTION: The present study evaluated the epidemiology of cryptococcal meningitis and TNFα gene polymorphisms in patients at a reference hospital in northern Brazil. METHODS: Samples from 25 patients infected with Cryptococcus spp. were collected to confirm the infection and to analyze the TNFα gene polymorphisms. RESULTS: Cryptococcus neoformans was detected as the predominant etiological agent (100%) in HIV-positive patients. No genetic polymorphic changes were found. CONCLUSIONS: No correlation was observed between the analyzed TNFα polymorphisms and cryptococcal meningitis.

Bibliographic Details

Main Authors:	Diniz,Alena Mileo Monteiro, Feio,Danielle Cristinne Azevedo, Silva,Aniel de Sarom Negrão, Burbano,Rommel Rodríguez, Lima,Patrícia Danielle Lima de
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2019
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100658
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