Relationships between phagocytosis, mucoid phenotype, and genetic characteristics of Klebsiella pneumoniae clinical isolates

Abstract INTRODUCTION The relationships between phagocytosis, and mucoid phenotype, plasmid profile and virulence, and resistance genetic characteristics of Klebsiella pneumoniae clinical isolates were evaluated. METHODS Thirty isolates were used to determine the mucoid aspect. Four were selected for analysis of phagocytosis by alveolar macrophages. RESULTS Thirty percent of the samples presented the mucoid phenotype. The phagocytosis rate ranged from 21.5% to 43.43%. Phagocytosis was not correlated with the plasmid profile, but was apparently correlated with mucoid phenotype and antibiotic susceptibility. CONCLUSIONS: Several virulence factors act in parallel in K. pneumoniae to impair host defense.

Bibliographic Details

Main Authors:	Cavalcanti,Francinete Carla Nunes, Rodrigues,Juliana Falcão, Cabral,Adriane Borges, Azarias,Larissa Caina Barbosa de, Morais Júnior,Marcos Antônio de, Castro,Célia Maria Machado Barbosa de, Lopes,Ana Catarina de Souza
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2019
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100648
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