TGF-β1 polymorphism in American tegumentary leishmaniasis in a Southern Brazilian population

TGF-β1 polymorphism in American tegumentary leishmaniasis in a Southern Brazilian population

Abstract INTRODUCTION: Genetic polymorphisms define the cytokine production leading to susceptibility or resistance to diseases. We studied the cytokine polymorphism in the development of tegumentary leishmaniasis (TL). METHODS: Genotyping of TNF-α, TGF-β1, IFN-γ, IL-6, and IL-10 were performed by polymerase chain reaction assay. RESULTS: G and C alleles of TGF- β1 (codon 25) were the most common in controls and patients, respectively. G/G was the most frequent genotype in controls, and G/C and C/C in patients. CONCLUSIONS: G/G genotype of codon 25 in TGF-β1 appeared to confer resistance, and G/C and C/C genotypes, susceptibility to TL in this population.

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Bibliographic Details
Main Authors: Shehadeh,Fabiane Vieira Berg, Santos,Rosiane Ribeiro dos, Silva,Laiane Alzira Denski da, Silva Júnior,Waldir Veríssimo da, Ribas-Silva,Rejane, Ribas,Adriana Danmvolf, Silveira,Thaís Gomes Verzignassi, Borelli,Sueli Donizete, Aristides,Sandra Mara Alessi
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Medicina Tropical - SBMT 2019
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100610
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