Stress conditions in the host induce persister cells and influence biofilm formation by Staphylococcus epidermidis RP62A

Abstract INTRODUCTION: Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival. METHODS: Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host. RESULTS: Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture. CONCLUSIONS: These findings highlight the role of host stress in the virulence of S. epidermidis.

Bibliographic Details

Main Authors:	Fraiha,Rafael Ovando, Pereira,Ana Paula Ramos, Brito,Eliana da Costa Alvarenga, Borges,Clayton Luiz, Parente,Ana Flávia Alves, Perdomo,Renata Trentin, Macedo,Maria Ligia Rodrigues, Weber,Simone Schneider
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2019
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822019000100608
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