Impact of Bacille Calmette-Guérin revaccination on serum IgE levels in a randomized controlled trial

Abstract INTRODUCTION: Bacille Calmette-Guérin (BCG) downmodulates allergen-specific IgE levels and prevents other atopic responses in experimental models but fails to protect against respiratory allergies. Human responsiveness to BCG is variable and may interfere with protection. METHODS: Multivariate models were evaluated to test the possible effect of responsiveness (assessed by IFN-γ production) to BCG revaccination on the modulation of total and allergen-specific serum IgE levels in healthy volunteers participating in a randomized controlled trial. RESULTS: Serum total or Derp-specific IgE levels did not change regardless of the increase in IFN-γ levels. CONCLUSIONS: BCG responsiveness does not affect protection against atopy.

Bibliographic Details

Main Authors:	Peleteiro,Thaís Silva, Oliveira,Evelin Santos, Conceição,Elisabete Lopes, Nascimento-Sampaio,Francisco, Alcântara-Neves,Neuza Maria, Mendes,Carlos Mauricio Cardeal, Bessa,Theolis Costa Barbosa
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2018
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822018000100094
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