Adverse systemic reaction to benznidazole

Abstract Benznidazole, drug of choice for Chagas disease (CD), has been associated with a high incidence of adverse reactions that can become serious, necessitating discontinuation of the drug. We describe the case of a Bolivian patient living in Spain for 9 years, who, following treatment with benznidazole for CD in indeterminate chronic phase, presented with fever, skin lesions, digestive symptoms, general malaise, and laboratory abnormalities. After the discontinuation of benznidazole and, the intake of antihistamines and systemic corticosteroids, the patient presented a complete resolution of the symptoms. Optimization of dose strategies and development of more effective, and better-tolerated drugs is advisable.

Bibliographic Details

Main Authors:	Coronel,María Verónica Pacheco, Frutos,Laura Oriente, Muñoz,Eva Calabuig, Valle,Diana Kury, Rojas,Dolores Hernández Fernández de
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2017
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822017000100145
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