There is no evident correlation between interleukin-10 gene polymorphisms and periportal fibrosis regression after specific treatment

Abstract INTRODUCTION: We evaluated the associations between interleukin-10 (IL-10) gene polymorphisms -G1082A/-C819T/-C592A and periportal fibrosis regression after specific treatment for schistosomiasis. METHODS: This retrospective cohort study involved 125 Brazilian patients infected with Schistosomiasis mansoni, who were followed up for 2 years after specific treatment to estimate the probability of periportal fibrosis regression. RESULTS: There was no evidence of associations between IL-10 polymorphisms and periportal fibrosis regression after treatment. CONCLUSIONS: There was no evidence of associations between gene promoter polymorphisms of IL-10 and the regression of periportal fibrosis in this Brazilian population.

Bibliographic Details

Main Authors:	Silva,Paula Carolina Valença, Silva,Aline Vieira da, Silva,Taysa Nascimento, Vasconcelos,Letícia Moura de, Gomes,Adriana Vieira, Coêlho,Maria Rosângela Cunha Duarte, Muniz,Maria Tereza Cartaxo, Domingues,Ana Lúcia Coutinho
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822016000600781
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