Detection of Leishmania (Viannia) DNA in leucocytes from the blood of patients with cutaneous leishmaniasis

ABSTRACTINTRODUCTION:Cutaneous leishmaniasis (CL) is a serious and global public health issue, with the potential of developing a mucosal form, occurring as subclinical cases, and showing recurrence despite previous treatment.METHODS:Polymorphonuclear and mononuclear DNA obtained from 49 patients was subjected to polymerase chain reaction for detection of Leishmania (Viannia).RESULTS:DNA was detected in mononuclear cells from two patients with active primary lesions positive for CL, with infection periods of 3 and 6 months, respectively.CONCLUSIONS:The DNA of Leishmania (Viannia) indicates probable parasite dissemination possibly explaining subclinical case emergence, lesion recurrence, and mucosal lesion appearance.

Bibliographic Details

Main Authors:	Conter,Carolina Cella, Neitzke-Abreu,Herintha Coeto, Pedroso,Raissa Bocchi, Lonardoni,Maria Valdrinez Campana, Silveira,Thaís Gomes Verzignassi, Aristides,Sandra Mara Alessi
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2015
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000500626
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