Influence of a subinhibitory concentration of vancomycin on the in vitro expression of virulence-related genes in the vancomycin-resistant Enterococcus faecalis

ABSTRACTINTRODUCTION:Exposure to subinhibitory concentrations (SICs) of antimicrobials may alter the bacterial transcriptome.METHODS: Here, we evaluated the expression of nine virulence-related genes in vancomycin-resistant enterococci (VRE) urinary tract infection isolates grown at SICs of vancomycin.RESULTS:A Subinhibitory concentrations of vancomycin interferes with gene modulation, but does not affect the phenotype of a VRE strain in vitro .CONCLUSIONS:Subinhibitory concentrations of vancomycin may regulate the expression of virulence factors in vivo or contribute to the selection of vancomycin-resistant strains.

Bibliographic Details

Main Authors:	Moura,Tiane Martin de, Campos,Fabrício Souza, Caierão,Juliana, Franco,Ana Claudia, Roehe,Paulo Michel, d'Azevedo,Pedro Alves, Frazzon,Jeverson, Frazzon,Ana Paula Guedes
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2015
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000500617
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