Clinical and serological evolution in chronic Chagas disease patients in a 4-year pharmacotherapy follow-up: a preliminary study

Introduction The role of trypanocidal therapy in the chronic phase of Chagas disease remains controversial. Methods A total of 13 patients with chronic Chagas disease were treated with benznidazole (5mg/kg/day/60 days) and surveyed via antibody measurement and conventional electrocardiogram over the course of 4 years. Results The antibody titers were significantly reduced after 4 years (p<0.05). Most of the patients showed maintenance of the initial clinical picture (electrocardiographic), with the exception of 4 cases. Conclusions Although trypanocidal therapy in the chronic phase of Chagas disease was of limited effectiveness, we believe that it is beneficial in treating these patients.

Bibliographic Details

Main Authors:	Andrade,Monica Coelho, Oliveira,Maria de Fatima, Nagao-Dias,Aparecida Tiemi, Coelho,Ivo Castelo Branco, Candido,Darlan da Silva, Freitas,Erlane Chaves, Coelho,Helena Lutescia Luna, Bezerra,Fernando Schemelzer Moraes
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Medicina Tropical - SBMT 2013
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822013000600776
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