AMERICAN CUTANEOUS LEISHMANIASIS WITH UNUSUAL CLINICAL PRESENTATION AND RESPONSE TO TREATMENT

The clinical manifestations and prognosis of cutaneous leishmaniasis (CL) can be influenced by the immune response of the patient and the species of the parasite. A case of atypical clinical presentation of CL, with development of non-characteristic lesions, poor response to therapy, and a long time to resolution is reported. Confirmatory laboratory tests included parasite detection, indirect immunofluorescence, Montenegro skin test, polymerase chain reaction, and parasite identification by multilocus enzyme electrophoresis. The parasite was identified as Leishmaniabraziliensis. The lesion was unresponsive to three complete courses of N-methylglucamine antimoniate intramuscular, and to treatment with pentamidine. The patient did not tolerate amphotericin B. The lesion finally receded after treatment with intravenous N-methylglucamine antimoniate. It is essential to ensure the accuracy of diagnosis and the appropriate treatment, which can include the use a second choice drug or a different route of administration.

Bibliographic Details

Main Authors:	FERNANDES,Andrea Claudia Bekner Silva, PEDROSO,Raíssa Bocchi, VENAZZI,Eneide Aparecida Sabaini, ZANZARINI,Paulo Donizeti, ARISTIDES,Sandra Mara Alessi, LONARDONI,Maria Valdrinez Campana, SILVEIRA,Thaís Gomes Verzignassi
Format:	Digital revista
Language:	English
Published:	Instituto de Medicina Tropical de São Paulo 2016
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652016005000401
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