Synergistic action of praziquantel and host specific immune response against Schistosoma mansoni at different phases of infection
The interaction between specific immune response to Schistosoma mansoni and praziquantel (PZQ) was studied in mice. In mice harboring concomitant immunity, 6-day-old parasites treated with PZQ were more effectively removed than 24h treated parasites despite both had a significant worm burden reduction when compared with respective treated controls. These results show that PZQ can be effective at the skin and lung stages of parasite's development mainly acting with a established specific immune response, and particularly at the lung phase.
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| Main Authors: | , , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Instituto de Medicina Tropical de São Paulo
2004
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| Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652004000400010 |
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