Malaria at Humaita county, Amazonas state, Brazil: XVII — immune response in patients with Plasmodium falciparum according to gametocytes

In August 1983 the Authors studied 36 patients with Plasmodium falciparum malaria and 14 normal individuals born in Humaita region who had never had malaria, had no spleen enlargement and had negative parasitemia as well as passive hemagglutination. Medical histories were obtained and complete physical examination were performed in all of them just as blood tests, parasite density and lymphocyte typing. The lymphocytes were separated and then frozen in liquid nitrogen for later typing by rosette formation. The patients were divided in two groups according to the presence (13 patients) or abscence (23 patients) of gametocytes before treatment. Severe malaria was predominant in the group without gametocytes. The results showed a decrease in the T-cell numbers in Plasmodium falciparum acute malaria patients both with or without gametocytes before the treatment, while B-cell numbers were normal only in the patients with gametocytes. These observations as like as those previously reported by the Authors, permit to associate the presence of gametocytes in peripheral blood and normal number of B-cells in patients with mild Plasmodium falciparum malaria.

Bibliographic Details

Main Authors:	Meira,Domingos Alves, Curi,Paulo Roberto, Marcondes,Jussara, Matsuoka,Elinda Satie, Favrin,Marina A., El-Khoury,Albert Boutros, Motta,Norma Gerusa da Silva
Format:	Digital revista
Language:	English
Published:	Instituto de Medicina Tropical de São Paulo 1985
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651985000500001
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