Maternal MTHFR polymorphisms and risk of spontaneous abortion

OBJECTIVE: To asses the association between intake of folate and B vitamins and the incidence of spontaneous abortion (SA) according to the maternal methylenetetrahydrofolate reductase (MTHFR) polymorphisms (677 C>T and 1298 A>C). MATERIAL AND METHODS: We conducted a nested case-control study within a perinatal cohort of women recruited in the state of Morelos, Mexico. Twenty-three women with SA were compared to 74 women whose pregnancy survived beyond week 20th. Intake of folate and B vitamins respectively, was estimated using a validated food frequency questionnaire. Maternal MTHFR polymorphisms were determined by PCR-RFLP and serum homocysteine levels by HPLC. RESULTS: Carriers of MTHFR 677TT and 1298AC genotypes respectively showed an increased risk of SA (OR 677TT vs. CC/CT=5.0; 95% CI: 1.2, 20.9 and OR 1298 AC vs. AA=5.5; 95% CI: 1.1, 26.6). CONCLUSIONS: Our results support the role of MTHFR polymorphisms as a risk factor for SA, regardless of dietary intake of B vitamins.

Bibliographic Details

Main Authors:	Rodríguez-Guillén,María del Rosario, Torres-Sánchez,Luisa, Chen,Jia, Galván-Portillo,Marcia, Blanco-Muñoz,Julia, Anaya,Miriam Aracely, Silva-Zolezzi,Irma, Hernández-Valero,María A, López-Carrillo,Lizbeth
Format:	Digital revista
Language:	English
Published:	Instituto Nacional de Salud Pública 2009
Online Access:	http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0036-36342009000100006
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